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| Reactivity | Human Mouse |
| Tested applications | WB IHC FC |
| Recommended Dilution | WB 1:500 - 1:1000 IHC 1:50 - 1:100 FC 1:20 - 1:50 |
| Calculated MW | 18kDa |
| Observed MW | Refer to Figures |
| Immunogen | A synthetic peptide of human CFL1 |
| Storage Buffer | Store at 4℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Concentration | br |
| Synonym | CFL; CFL1;p18;Cofilin 1; |
The protein encoded by this gene can polymerize and depolymerize F-actin and G-actin in a pH-dependent manner. Increased phosphorylation of this protein by LIM kinase aids in Rho-induced reorganization of the actin cytoskeleton. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus.[supplied by OMIM, Apr 2004]
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