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+1-888.733.6849
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| Reactivity | Human Mouse Rat |
| Tested applications | WB ICC IP FC |
| Recommended Dilution | WB 1:500 - 1:2000 ICC 1:50 - 1:100 IP 1:50 - 1:100 FC 1:50 - 1:200 |
| Calculated MW | 38kDa |
| Observed MW | Refer to Figures |
| Immunogen | Recombinant protein of human CRK |
| Storage Buffer | Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Synonym | p38; CRKII; |
This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described.
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