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sales@neoscientific.com
+1-888.733.6849
+1-617.299.7367 (Int’l)
+1-888.733.6849
+1-617.299.7367 (Int’l)
| Reactivity | Human Mouse Rat |
| Tested applications | WB IHC |
| Recommended Dilution | WB 1:200 - 1:1000 IHC 1:50 - 1:100 |
| Calculated MW | 133kDa |
| Observed MW | Refer to Figures |
| Immunogen | Recombinant protein of human NUMA1 |
| Storage Buffer | Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Synonym | NUMA |
Western blot analysis of extracts of HeLa cell tissue, using NUMA1 antibody.
Immunohistochemistry of paraffin-embedded human gastric using NUMA1 antibody at dilution of 1:100 (x40 lens).
Immunohistochemistry of paraffin-embedded rat heart using NUMA1 antibody at dilution of 1:100 (x40 lens).
Immunohistochemistry of paraffin-embedded mouse stomach using NUMA1 antibody at dilution of 1:100 (x40 lens).
The nuclear mitotic apparatus protein (NuMA) is a coiled coil protein involved in the formation and maintenance of the mitotic spindle. NuMA plays a role in chromatin organization during interphase, which influences mammary epithelial differentiation (1,2). During apoptosis, carboxy-terminal cleavage of NuMA may amplify signaling in the cell death pathway (2). NuMA is phosphorylated at numerous sites, with phosphorylation at Ser395 occurring in an ATM/ATR-dependent manner in response to DNA damage (3,4).
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