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sales@neoscientific.com
+1-888.733.6849
+1-617.299.7367 (Int’l)
+1-888.733.6849
+1-617.299.7367 (Int’l)
| Reactivity | Human |
| Tested applications | WB IF FC |
| Recommended Dilution | WB 1:500 - 1:2000 IF 1:20 - 1:50 FC 1:20 - 1:50 |
| Calculated MW | 91kDa |
| Observed MW | Refer to Figures |
| Immunogen | A synthetic peptide of human UHRF1 |
| Storage Buffer | Store at 4℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Concentration | bl |
| Synonym | Np95; hNP95; ICBP90; RNF106; hUHRF1; |
UHRF1, also named as ICBP90, NP95 and RNF106, is a putative E3 ubiquitin-protein ligase. It may participate in methylation-dependent transcriptional regulation. UHRF1 binds to inverted 5'-CCAAT-3' box 2 in the TOP2A promoter, and activates TOP2A expression. It is important for G1/S transition and may be involved in DNA repair and chromosomal stability. UHRF1's ability to repress its direct target gene expression is dependent on PHD(UHRF1) binding to unmodified H3R2.
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