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| Reactivity | Human Rat |
| Tested applications | WB IHC IF IP FC |
| Recommended Dilution | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 IP 1:20 - 1:50 FC 1:20 - 1:50 |
| Calculated MW | 75kDa |
| Observed MW | Refer to Figures |
| Immunogen | Recombinant protein of human XRCC6 |
| Storage Buffer | Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Concentration | ej |
| Synonym | CTC75; CTCBF; G22P1; KU70; ML8; TLAA |
X-ray repair cross-complementing protein 6（XRCC6）gene encodes subunit p70 of the p70/p80 autoantigen which has a role in DNA repair or transposition. DNA helicase II complex binds preferentially to fork-like ends of double-standed DNA in a cell cycle-dependent manner, which may be mediated by XRCC6. XRCC6/5 can form a heterdimer, which function as a regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA, and also it can stablize broken DNA ends and bringing them together. Otherwise, XRCC5/6 heterdimer together with APEX1 can negatively regulate of transcription
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